The influence on the ability to drive and use machines is nil or negligible. Treatment of lesions of toxic-metabolic origin, especially those characterized by intense peroxidation, such as those caused by chronic consumption of alcohol and hepatotoxic drugs, fatty liver, alcoholic hepatitis and cirrhosis. For caps. 300 mg: traditional herbal medicine used in case of heavy digestion or dyspepsia due to liver disease, only because of its traditional use. Animal studies do not indicate direct or indirect adverse effects with respect to reproductive toxicity. However, since studies in pregnant women are not available and reproductive toxicity studies in animals do not always predict a response in humans, it should not be used during pregnancy unless the woman`s clinical condition requires treatment with silymarin. © Vademecum Vidal Source: The content of this monograph of the active substance according to the ATC classification has been written taking into account the clinical information of all medicinal products authorised and marketed in Spain classified in this ATC code. For detailed information on the information authorised by the AEMPS for each medicine, you should consult the data sheet approved by the AEMPS. Legalon is a drug used as liver therapy to prevent fat accumulation in the liver and repair liver damage. It is used in the treatment of: Silymarin or silibin has been shown to be helpful in improving liver tissue damage, as it is able to increase protein synthesis, which increases the ability of organic cells to regenerate. Similarly, it prevents the process of lipid peroxidation of the plasma membrane in liver cells, a process that causes a chain reaction that destroys cells and is characteristic of liver diseases such as cirrhosis. Legalon 150 mg contains the principle of silymarin, which acts as a stabilizer of the injured cell membrane, thereby providing complex protection of the liver gland from harmful influences, thereby achieving the restoration of already injured liver cells.
This is manifested by an improvement in the general condition, a decrease in digestive ailments, an increase in appetite and weight, an improvement in liver symptoms and normalization of values in clinical analysis. Indications lesions of toxic-metabolic origin, especially those characterized by intense peroxidation, caused by chronic alcohol consumption and hepatotoxic drugs: fatty liver, alcoholic hepatitis, cirrhosis of the liver. The appropriate dose of silymarin may be different for each patient. The most commonly recommended dosages are listed below. However, if your doctor has given you a different dose, do not change it without talking to your doctor or pharmacist. Drugs in children: The drug can be used from the first year of life. At the beginning of treatment, two tablets should be taken 3 times a day, and as a maintenance dose – 1 tablet 3 times a day. It is necessary to administer it after meals and with a glass of water. Treatment can last indefinitely, depending on the severity of the disease.
Silymarin also stimulates protein synthesis in liver cells. PRECAUTIONS AND SPECIAL WARNINGThe animal studies have shown no teratogenic effects However, administration during pregnancy is not recommended. The duration of treatment depends on the underlying condition for which it has been indicated. It can be administered indefinitely, as it has no cumulative or toxic effects. Silymarin, also called silibinin, is a drug that blocks the absorption of toxic substances (such as amatoxin, the main toxin in Amanita phalloides) by liver cells and reduces the concentration of toxic substances in liver cells and therefore their toxicity. Antioxidant, eliminates free radicals and disrupts peroxidative processes involved in liver damage. In Spain, oral (capsules) and parenteral (vial) dosage forms are available. It is not known whether silymarin or its metabolites are excreted in breast milk.
Therefore, the risk in newborns cannot be excluded. If you notice any of these symptoms, stop using Legalon and do not hesitate to call your doctor. Orally: 80-150 mg / 8 h, maintenance: 80-150 mg / 12 h. Duration: 4-6 weeks. For caps. 300 mg: 600-900 mg for lunch and dinner. To access dosage information in Vademecum.es, you will need to log in with your email address and password or register. CONTRAINDICATIONS AND WARNINGThe sensitivity to silymarin. Contact us and ask for more information.
Do you need the advice of a specialist? Book a consultation online: you will receive all the answers without leaving the house. So far, only a few cases of hypersensitivity to the active substance. Oral. Swallow the capsules with a little liquid after the main meals. Useful in the treatment of acute and chronic hepatitis, alcoholic hepatitis, fatty liver disease and cirrhosis. When treatment begins in adults, 2 tablets three times a day after meals. As a supportive dose, a dragee can be administered three times a day. In children over one year of age, 1 tablet three times a day, in cirrhosis of the liver 2 tablets 3 times a day. Not recommended for children and adolescents < 18 years of age; Long-term treatment (medical supervision). Our experts answered 138 questions about Legalon It is recommended to take silymarin after meals.